Circadian Rhythms, Peptides & Biological Efficiency
Circadian rhythms are used by your body to generate a roughly 24 hour cycle of biological processes. They are at the intersection where your external environment meets your internal physiology. Things such as light/darkness, temperature, activity and feeding/fasting times entrain your body to anticipate certain stimuli and prepare for it accordingly. You've learnt be be biologically efficient over your 3 billions years of evolution.
When you are younger these rhythms are robust and subsequently produce strong internal signalling. Yet as we age they become flattened and less pronounced. As a result signalling becomes weaker, less efficient and starts to fail.
Rhythms of life: circadian disruption and brain disorders across the lifespan - This is a great review giving insights into the detrimental effects of having a disrupted circadian system and why avoiding it is desirable.
From an anti-ageing perspective anything which can therefore restore an ageing hormonal profile or reestablish stronger circadian signalling is an incredibly useful tool. When it comes to regenerative processes sleep is the master. Understanding how Sleep in Normal Ageing can change and the processes involved quickly highlights the link between GH pulsation at night and slow wave sleep.
"Inhibition of growth hormone releasing hormone (GHRH) suppresses GH
secretion, promotes corticotrophin releasing hormone, and reduces SWS. Further, there
is an age-related decline in GH secretion. GH secretion reaches its peak during
adolescence, rapidly declines in an exponential manner between young adulthood and
middle age, and then declines slowly between middle to old age. This phenomenon is similar
to the detected age-related decrease of SWS. The decline in nocturnal GH with aging may
have a direct or indirect impact on SWS, and may be partially responsible for the observed
reduction of SWS in aging"
This is why GHRP's are an invaluable tool and why Ipamorelin should probably be part of an established nighttime protocol.
There are no single magic bullets in biology, yet if you're aiming to increase your healthspan and there is a way to maintain the amount of SWS from middle age (or even prior to that) across a whole lifespan, Ipamorelin and restoring GH pulses should definitely be one of the bullets added to your magazine.