Group Details Private

Global Moderators

Forum wide moderators

  • RE: Recovering from a hip fracture

    Thank you very much for sharing man. I love hearing about pleasantly surprised health care professionals! I know that BPC is most effective for tendon and ligament recovery, TB500 more muscular, with IGF-1 LR3 being a more general effect, and I've just been made aware of it's positive effect on osteoblastic activity. Obviously there's some tissue damage and inflammation that's beyond skelatal damage. You should put up the pic of your hardware - Iron Man!

    posted in Protocols for Healing
  • RE: Ipamorelin as a sleep aid

    Mark, me and TIC remembered about 'boom' dosing Ipamorelin a few nights ago and both took 300mcg as a standalone. We both reported a very restful and full night's sleep, deep enough to keep me asleep past my usual internal alarm clock.

    I might experiment with 500mcg. Actually I think I will first try 300mcg of Ipam and 100mcg of Mod-GRF to compare with my previous dose.

    I seem to recall, (I'll have to have a look at some point) that boom dosing creates multiple pulses of growth hormone throughout the subsequent hours, I can't remember for how long. I might have a graph to show it, that was formerly from Dat's. Anyway!

    It's very interesting because it creates a lot of 'time under tension' to use a weight training analogy, spent with high levels of growth hormone, but as it is still pulsatile, we don't get the negative effects of prolonged, elevated levels of growth hormone - one of which is a more female GH release pattern.

    Keen to find out how you get on mate.

    posted in Protocol for Sleep
  • RE: Circadian Rhythms, Peptides & Biological Efficiency

    @TimboSlice Thanks man. Glad to be able to inform and simultaneously pique your curiosity. Sure thing...

    So, whilst circadian are the near 24 hour rhythms, ultradian rhythms have a much shorter duration and occur within the circadian time structure. Numerous things like sleep cycles, GH pulsation, and heart rate would all be considered ultradian. If you wanted to know more this review is a great read and was what got me curious about biological rhythms a few years ago.

    But yes, the skin is a deeply complicated organ. I always wish i knew more about it as there's so much going on. Makes me consider exploring transdermal administration a bit more too. Nice study by the way.

    I can definitely compose something on sleep hygiene over the next few days. Probably warrants starting a fresh for that though?

    Slightly in keeping with skin and tanning, you might want to look at Botanical Craft and red palm oil extract. It's got some interesting science behind it and might aid you in the summer months.

    posted in Protocols for Anti-aging
  • Carbless Post-Workout and Peptides

    I'm going to put this here until we possibly have another sub forum for Nutritional strategies, but I wanted to share and stoke discussion on carbless PWO, a method of eating whereby you eat carbohydrates in the hours leading to your workout, and then simply omit carbohydrates for around 5 or more hours after you have exercised.

    The idea behind is that as glycogen is the preferred source of fuel for the brain, after you deplete glycogen stores through exercise, the body will look to save what is left and look to other sources of fuel, i.e fat, as long as you have sufficient amino acids in the pool. Contrary to popular belief, grown through a lot of repetition about the importance of 'replenishing glycogen' post workout. There is something to be said about the role of insulin in muscle building, and it's proteosome inhibitory effect, however, all it takes to initiate muscle protein synthesis is the presence of amino acids in the blood, [in particular leucine]. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041535/)

    People always talk about the amount of calories burnt during exercise but it is a very inefficient focus. Instead, think of the exercise as an event, and the subsequent state the body is then in as the time spent utilising fat as an energy source. The PWO meals usually consist of meat or eggs, and possibly some sort of greenery, a salad, cruciferous vegetables (which do have carbs in but are negligable in effect) protein basically. Naturally there will be some fat with those meals, but you don't want to go overboard here, it's a little like filling a hole with dirt only to dig it all out again.

    You can eventually take in some carbs here later in the day but I don't like to go for too many - just enough to curb the cravings or possible mild hypoglycemic symptoms.

    In my experience, peptides are an excellent addition to this protocol, any of those that illicit lipolysis (the releasing of fatty acids from stores, into the blood. GH Frag, Melanotan II, PT141 and the those from the GHRP family, taken preworkout. Or a combination of them (not MT and PT though imo)

    Recently, I have been utilising GH Frag and Ipam around 45 minutes before I get to the gym, whether it be combat sports or weight training so that as I get deeper into my workout, I have depleted glycogen sufficiently to start to use those liberated fatty acids as fuel. You could also take more peptides post workout, which I may tend to do if I'm training in the AM but it all depends on your goals. Mine has predominately always been muscle accrual, interspersed with the odd fat loss phase just to experiment, so I usually don't bother and get more much needed (for me) calories in at this stage.

    Sometimes I'll also add MTII/PT141 but I don't like to do this later on due to it's possible effect on circadian rhythms
    That and I tend to go exceptionally red-faced post Melanotan injection lol.

    posted in Protocols for Fat Loss
  • RE: Circadian Rhythms, Peptides & Biological Efficiency

    Mate, love the whole post. You not only confirmed what I'd been told, but enveloped me in knowledge 👍 And also created a few questions. firstly, what's the difference between ultradian? I'm already googling it but I thought I'd still ask for the benefit of the post, and of the forum for that matter.

    I especially like the graphic. I was looking to understand what a 'barrier recovery' rate was and found this abstract trying to understand what it means - which I succeeded in doing, but it also showed me how very complicated it is!

    I ask about the melanotan and it can give me a flushing effect and I prefer not to look that red-faced at work or around people because it can be quite pronounced! I may look into PT141 because I finally have a good hygienic sleep pattern and I want to keep it that way. Plus I don't want to turn really really brown like our friend 😬

    I would love to hear your thoughts on sleep hygiene by the way.

    posted in Protocols for Anti-aging
  • RE: Step 1 up from 'just' steroids?

    Excellent post my man. I remember when I first started using Mod-GRF and GHRP-6 back on dat place, using it at 100mcg initially pre-bed but ramping up to 5-6 times a day within a day or 2 😂 Saturation dose was have been 70mcg using the 1mcg per KG saturation dosing for me at the time. It can be difficult at this kind of schedule because of the blunting effects of food but it's not impossible.

    Of course you don't have to go balls deep, in fact, I would recommend a good few pre-bed dosing only, then introduce a morning dose (this could be be semi-fasted) followed by pre-workout around 30-40min before you hit the gym IIRC. Better to milk the effects of the lower doses.

    I used to like GHRP-6 because muscle gain has always been my goal, when I do train to build my physique as opposed to performance. This is due to it's action as a ghrelin mimetic, ghrelin being the 'hunger hormone'. I recall a couple of times pinning 300mcg and going to a Brazilian all you can eat BBQ 😆 Ingesting meat until you sweat isn't probably the healthist thing thing to do especially regularly mind you. Some people with different goals, avoid using GHRP-6 for this reason, opting for Ipamorelin.

    I have used GH before, but I'm not comfortable really comparing the two because of my inexperience with 177 growth hormone, but I really enjoyed the effects of supplementing anabolic and androgenic steroids with judicious use of peptides. Certainly from a performance enhancing (over simply aesthetic) perspective, it has a tremendous effect. Peptides such as MGF, IGF-1, and TB500 alongside a low dose of oral steroids made a huge difference for me in strength in combat sports, both grappling and striking disciplines (we can have a discussion on the morality of PED use in sports, especially combat sports - my views are probably hypocritical, demonstrably) through direct action in/on the ring/mats and when at home resting and digesting, healing those sore bones that only fighting seems to give you.

    TIC, what is the mechanism of the blunting effect that certain food groups have upon the GH secretagogues, how much of effect is it? I remember seeing a graph that showed just how badly it effected it but it's just a snapshot in my mind.

    posted in Peptide and Steroid Advanced Discussion
  • RE: Circadian Rhythms, Peptides & Biological Efficiency

    @TimboSlice Hmmm, I can't say I've looked at that peptide specifically. Biological Rhythms in the Skin do have a circadian (as well as ultradian) component however.

    Morning dosing could be a wise choice. During the day your skin is more resilient and better suited at contending with insults, UV light, ROS etc. At night, like many other processes is when it "heals" and repairs.

    skin.jpg

    Night time dosing could risk sleep disruption depending upon how well you tolerate it, which is obviously preferable to avoid. The skin is a complicated organ but Human epidermal stem cell function is regulated by circadian oscillations too.

    You'd probably need to look at the alpha-Melanocyte-stimulating hormone profile to ascertain more....

    "Serum cortisol concentrations (P < 0.01), but not plasma ACTH or α-melanocyte-stimulating hormone (α-MSH), showed a significant circadian periodicity in horses. An effect of season on hormone concentration was observed with plasma ACTH and α-MSH concentration greater in the fall and cortisol concentration greater in the spring"

    Just dug that up from a study in horses. Maybe increased/decreased dosing seasonally might be a consideration? But at this point 🤷

    posted in Protocols for Anti-aging
  • RE: Circadian Rhythms, Peptides & Biological Efficiency

    Very interesting AdamZeus, I was wondering when you would bring some circadian rhythm knowledge and discussion to the party.

    I know here you speak of the benefits for Ipamorelin and other GHRP's, specifically for anti-aging. Anecdotally, I have certainly experienced an improvement in the quality of my sleep when using these peptides, but do you know of any other peptides that may have a negative effect on circadian rhythm, say, Melanotan II? I have only ever used it in the morning as I think I remember TIC mentioning something. I'd love to hear more from you regarding circadian rhythms.

    posted in Protocols for Anti-aging
  • RE: Interesting site!

    Welcome! Thanks for posting, I'm also looking forward to seeing this place develop. If you're a regular peptide user, perhaps you'd like to share some of your experiences in the ' Share Your Peptide Experiences Here ' section. It's always interesting hear how each individual has incorporated peptides into their lives, for any one or more of the multitude of benefits these amino acids can bring us.

    posted in Announcements
  • Circadian Rhythms, Peptides & Biological Efficiency

    Circadian Rhythms, Peptides & Biological Efficiency

    Circadian rhythms are used by your body to generate a roughly 24 hour cycle of biological processes. They are at the intersection where your external environment meets your internal physiology. Things such as light/darkness, temperature, activity and feeding/fasting times entrain your body to anticipate certain stimuli and prepare for it accordingly. You've learnt be be biologically efficient over your 3 billions years of evolution.

    When you are younger these rhythms are robust and subsequently produce strong internal signalling. Yet as we age they become flattened and less pronounced. As a result signalling becomes weaker, less efficient and starts to fail.

    Rhythms of life: circadian disruption and brain disorders across the lifespan - This is a great review giving insights into the detrimental effects of having a disrupted circadian system and why avoiding it is desirable.

    From an anti-ageing perspective anything which can therefore restore an ageing hormonal profile or reestablish stronger circadian signalling is an incredibly useful tool. When it comes to regenerative processes sleep is the master. Understanding how Sleep in Normal Ageing can change and the processes involved quickly highlights the link between GH pulsation at night and slow wave sleep.

    "Inhibition of growth hormone releasing hormone (GHRH) suppresses GH
    secretion, promotes corticotrophin releasing hormone, and reduces SWS. Further, there
    is an age-related decline in GH secretion. GH secretion reaches its peak during
    adolescence, rapidly declines in an exponential manner between young adulthood and
    middle age, and then declines slowly between middle to old age. This phenomenon is similar
    to the detected age-related decrease of SWS. The decline in nocturnal GH with aging may
    have a direct or indirect impact on SWS, and may be partially responsible for the observed
    reduction of SWS in aging"

    This is why GHRP's are an invaluable tool and why Ipamorelin should probably be part of an established nighttime protocol.

    There are no single magic bullets in biology, yet if you're aiming to increase your healthspan and there is a way to maintain the amount of SWS from middle age (or even prior to that) across a whole lifespan, Ipamorelin and restoring GH pulses should definitely be one of the bullets added to your magazine.

    posted in Protocols for Anti-aging